Jobs at Arbor Biotechnologies

We are seeking an Associate Scientist to participate in protein engineering campaigns for our cutting-edge genome editing tools towards generating best-in-class molecules. You will play a key role in supporting selection and generation of protein mutants/variants, for testing in cellular screens, downstream analytics, and communicating results within the team. You will also work cross-functionally with other teams to support upstream design and downstream hand-off and testing. This role is ideal for a detail-oriented and motivated molecular biologist with a willingness to learn and a team-first mentality.

• Independently plan, execute, optimize, and troubleshoot experiments supporting protein engineering campaigns for genome editing tools.
• Contribute to the design, generation, and evaluation of protein mutants/variants, including recommending experimental approaches, controls, and follow-up studies.
• Design and execute cell-based screening workflows using transient transfection, nucleofection, and transduction in dividing and non-dividing cell models.
• Design, package, and evaluate AAVs for protein variant testing, including troubleshooting production, delivery, and performance issues.
• Synthesize, purify, characterize, and test IVT-generated mRNA, including troubleshooting quality, yield, and cellular delivery.
• Prepare sequencing libraries and analyze experimental outputs to assess editing outcomes, variant performance, and experimental quality.
• Interpret data, summarize conclusions, and make recommendations that inform next-step experiments and campaign decisions.
• Maintain high-quality documentation and prepare clear data packages for cross-functional review.
• Collaborate with upstream design and downstream testing teams on experimental planning, prioritization, and handoff.
• Present results and contribute scientific input to project planning and experimental strategy.

• Bachelor's degree in biology, biochemistry, molecular biology, or related discipline with a minimum of 8 years of related experience, or Master's degree with a minimum of 6 years of relevant experience; industry experience preferred.
• Demonstrated ability to independently execute and optimize complex molecular biology, cell-based assay, and protein variant evaluation workflows.
• Hands-on experience with AAV production and testing, including vector design, packaging, assay execution, and troubleshooting of production or performance issues.
• Hands-on experience with IVT mRNA synthesis, purification, characterization, and cellular delivery, including troubleshooting quality, yield, and transfection/nucleofection performance.
• Strong tissue culture experience, including transient transfection, nucleofection, or transduction in dividing and/or non-dividing cell types; experience with primary cells is a plus.
• Experience contributing to experimental design, data interpretation, and recommendation of next-step studies.
• Ability to manage multiple experiments or workstreams with general guidance and communicate results clearly to scientific stakeholders.
• Experience with CRISPR gene editing technologies is a plus.
• Familiarity with Illumina sequencing workflows is a plus.

Attributes for Success.

• Detail-oriented & motivated
• Willingness to learn
• Flexible mindset
• Clear and friendly communication
• Team-first attitude