Jobs at Centessa Pharmaceuticals

We are seeking an analytically elite, strategically minded Senior Scientist to join our Safety Assessment team. This is a 100% non-laboratory position designed for a seasoned bioscientist or toxicology operations expert who thrives at the intersection of dataset auditing, mechanistic evaluation, and cross-functional project leadership.

• Advanced Data Visualization & Analytics: Lead the architectural design and execution of data models that transform raw, multi-dose toxicology data streams, clinical pathology tables, and safety pharmacology metrics into publication-ready visual tools (e.g., exposure-margin heatmaps, benchmark dose plots, and cumulative trend diagnostics) to clearly define therapeutic windows.
• SEND Strategy & Regulatory Auditing: Oversee the review and quality control of incoming Standard for the Exchange of Nonclinical Data (SEND) datasets from CRO vendors. Ensure absolute compliance, schema validation, and exact data alignment with finalized nonclinical study reports prior to regulatory filing and archival.
• Mechanistic Synthesis & Literature Architecture: Conduct rigorous, comprehensive scientific literature investigations to proactively assess target-mediated or chemotype-specific safety risks. Synthesize complex, ambiguous biological data into clear, actionable technical memos that inform investigative toxicity strategies.
• PDT & Governance Leadership: Partner closely with Toxicology Leads to co-author high-impact data packages, briefing books, and executive slide decks. Actively participate in defending safety strategies and securing program endorsements within Project Development Teams (PDTs) and formal internal governance panels.
• Cross-Functional Synergy: Act as a senior scientific liaison between Safety Assessment, CMC (for compound inventory tracking), DMPK (for toxicokinetic integration), and Project Management to ensure nonclinical safety deliverables map smoothly to aggressive global project milestones.

• Education: B.S. or M.S. degree in Toxicology, Pharmacology, Cellular/Molecular Biology, Bioinformatics, or a related life sciences discipline.
• Experience Required:
• With an M.S. degree: 6–8+ years of highly relevant biotechnology, pharmaceutical, or tier-one CRO industry experience.
• With a B.S. degree: 8–10+ years of extensive industrial drug-development, data management, and toxicology operations experience.
• Core Technical Competencies:
• Expert-level understanding of preclinical toxicology datasets, histopathology reporting structures, and study designs.
• Hands-on proficiency auditing, validating, or working directly with regulatory SEND data structures.
• Advanced capability utilizing scientific data software to build complex data structures (e.g., GraphPad Prism, Spotfire, Excel macros, or specialized Python/R data visual tools).
• Leadership & Influence: Superb technical writing skills paired with a demonstrated ability to distill vast pools of complex data into clear arguments capable of convincing diverse, cross-functional scientific leaders.